The family of drugs loosely known as “narcotics” includes chemicals in the opiate family, such as heroin, along with cocaine and variations of methamphetamine (“speed”). All of these drugs produce intense psychological symptoms during withdrawal, and most cause physical symptoms as well, making them some of the most addictive substances known.
The process of overcoming narcotic addiction involves short-term assistance to ease the immediate withdrawal period, and long-term psychological work to induce behavior change, and, in some cases, maintenance treatment with long-acting narcotics such as methadone . New classes of medications are under investigation for aiding withdrawal as well.
There are no well established natural treatments to aid the treatment of drug addiction, but some have shown a bit of promise.
The herb
passionflower
is thought to have mild sedative properties, and has been suggested as an aid to drug withdrawal. A 14-day,
double-blind trial
enrolled 65 men addicted to opiate drugs and compared the effectiveness of passionflower combined with the drug clonidine to clonidine alone.
1
Clonidine is used widely to assist in narcotic withdrawal. It effectively reduces physical symptoms, such as increased blood pressure. However, it does not help emotional symptoms, such as drug-craving, anxiety, irritability, agitation, and depression. These symptoms can be quite severe, and they often cause enrollees in drug treatment programs to end participation.
In this 14-day study, the use of passionflower along with clonidine significantly eased the emotional aspects of withdrawal compared to use of clonidine alone. However, more research will be necessary to prove this treatment effective.
Although some animal studies suggest that various forms of
acupuncture
may have some benefits for chemical dependency,
2,3
study results in humans have been mixed at best, with the largest studies reporting no benefits.
For example, a single-blind, placebo-controlled trial that evaluated 620 cocaine-dependent adults found acupuncture no more effective than sham acupuncture or relaxation training.
4
Similarly, a single-blind, placebo-controlled study enrolling 236 residential clients found no benefit from ear acupuncture for cocaine addiction.
5
However, benefits
were
seen in a much smaller single-blind trial.
6
Finally, a single-blind, controlled trial of 100 participants with heroin addiction evaluated the potential benefits of ear acupuncture.
7
However, a high dropout rate makes the results difficult to interpret.
One study provides weak evidence that the substance
N-acetylcysteine
might be helpful for treating cocaine dependence.
17
Similarly weak evidence hints at potential benefits for opiate addiction with the herbs
brahmi
(
Bacopa monniera
),
13rosemary
,
14
and
velvet antler
.
15-16
Weak evidence hints that the substance lobeline from the herb
lobelia
might offer benefit for methamphetamine addiction.
10-12
A 10-week, double-blind trial failed to find
ginkgo
helpful for cocaine dependence.
8
One study failed to find
hatha yoga
helpful for enhancing the effectiveness of a methadone maintenance treatment for heroin addiction.
9
Akhondzadeh S, Kashani L, Mobaseri M, et al. Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial.
J Clin Pharm Ther.
2001;26:369–373.
Cheng RS, Pomeranz B, Yu G. Electroacupuncture treatment of morphine-dependent mice reduces signs of withdrawal, without showing cross-tolerance.
Eur J Pharmacol.
1980;68:477–481.
Ng LK, Douthitt TC, Thoa NB, et al. Modification of morphine-withdrawal syndrome in rats following transauricular electrostimulation: an experimental paradigm for auricular electroacupuncture.
Biol Psychiatry.
1975;10:575–580.
Margolin A, Kleber HD, Avants SK, et al. Acupuncture for the treatment of cocaine addiction: a randomized controlled trial.
JAMA.
2002;287:55–57.
Bullock ML, Kiresuk TJ, Pheley AM, et al. Auricular acupuncture in the treatment of cocaine abuse. A study of efficacy and dosing.
J Subst Abuse Treat.
1999;16:31–38.
Avants SK, Margolin A, Holford TR, et al. A randomized controlled trial of auricular acupuncture for cocaine dependence.
Arch Intern Med.
2000;160:2305–2312.
Washburn AM, Fullilove RE, Fullilove MT, et al. Acupuncture heroin detoxification: a single-blind clinical trial.
J Subst Abuse Treat.
1993;10:345–351.
Kampman K, Majewska MD, Tourian K, et al. A pilot trial of piracetam and ginkgo biloba for the treatment of cocaine dependence.
Addict Behav
. 2003;28:437–448.
Shaffer HJ, LaSalvia TA, Stein JP. Comparing Hatha yoga with dynamic group psychotherapy for enhancing methadone maintenance treatment: a randomized clinical trial.
Altern Ther Health Med
. 1997;3:57–66.
Miller DK, Crooks PA, Teng L, Witkin JM, Munzar P, Goldberg SR, Acri JB, Dwoskin LP. Lobeline inhibits the neurochemical and behavioral effects of amphetamine.
J Pharmacol Exp Ther
. 2001 Mar;296(3):1023-34.
Dwoskin LP, Crooks PA. Related Articles A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse.
Biochem Pharmacol.
2002 Jan 15;63(2):89-98. Review.
Harrod SB, Dwoskin LP, Crooks PA, Klebaur JE, Bardo MT. Lobeline attenuates d-methamphetamine self-administration in rats.
J Pharmacol Exp Ther.
2001 Jul;298(1):172-9.
Sumathi T, Nayeem M, Balakrishna K, Veluchamy G, Devaraj SN. Alcoholic extract of 'Bacopa monniera' reduces the in vitro effects of morphine withdrawal in guinea-pig ileum.
J Ethnopharmacol.
2002 Oct;82(2-3):75-81
Hosseinzadeh H, Nourbakhsh M. Effect of Rosmarinus officinalis L. aerial parts extract on morphine withdrawal syndrome in mice.
Phytother Res
. 2003;17:938-41
Kim HS, Lim HK, Park WK. Antinarcotic effects of the velvet antler water extract on morphine in mice.
J Ethnopharmacol.
1999;66:41-49.
Kim HS, Lim HK. Inhibitory effects of velvet antler water extract on morphine-induced conditioned place preference and DA receptor supersensitivity in mice.
J Ethnopharmacol.
1999;66:25-31.
Larowe SD, Myrick H, Hedden S, et al. Is cocaine desire reduced by N-acetylcysteine?
Am J Psychiatry.
2007;164:1115-1117.
Last reviewed October 2007 by EBSCO CAM Medical Review Board
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