WEDNESDAY, April 23 (HealthDay News) -- New research suggests
that scientists are close to developing a simple way to measure
oxygen levels in tumors, giving doctors a heads-up about what kind
of treatment is best for individual patients.
The findings fit into an emerging trend of individualized
treatment for patients with cancer instead of treating people the
same way, said Dr. Mark Dewhirst, a professor of radiation oncology
at Duke University Medical Center.
"If successful, [the trend] will revolutionize the way that we
treat cancer," said Dewhirst, who co-wrote a commentary
accompanying the new study, published April 22 in the
Journal of Clinical Investigation.
Scientists began realizing the important role of oxygen in
tumors about 50 years ago, said study co-author James Mitchell,
branch chief of radiation biology at the U.S. National Cancer
Institute's Center for Cancer Research. The scientists discovered
that tumors with higher concentrations of oxygen were more
susceptible to radiation, he said.
"Radiation damages cells by causing damage to DNA, and one
particular type of damage renders the DNA molecule non-reparable,"
Mitchell said. But less oxygen in the tumor allows tumor cells to
survive more easily by making the DNA destruction process more
difficult, he said.
According to Dewhirst, the same is true for chemotherapy drugs,
which also don't work as well when tumors have less oxygen.
Lower levels of oxygen create other problems, Dewhirst. "One
would think at first that lack of oxygen would make tumors
unhealthy and easy to kill," he said. "But actually, the opposite
happens -- tumor cells that lack oxygen become more aggressive and
more difficult to kill."
Tumors with lower oxygen levels even spread more easily through
the body, he said.
Doctors can check oxygen levels in patients by inserting a
needle. But doctors can't insert needles into some patients, and.
in others, it's difficult to insert the needle deep enough,
Mitchell said.
In the new study, the researchers tested a scanning technique
called pulsed electron paramagnetic resonance imaging and used it
in tandem with magnetic resonance imaging. The study authors said
they were able to successfully measure oxygen levels in tumors in
mice by using the non-invasive technology.
"The imaging that is described in this study provides all of the
information necessary to evaluate oxygen levels in tumors as well
as to examine underlying causes for the lack of oxygen," Dewhirst
said. "The fact that all of the imaging is completely non-invasive
provides the ability to perform this measurement more than once,
(meaning) this could be used to monitor the effectiveness of cancer
therapy."
There are caveats, however. The research hasn't reached the
human testing level yet, and it may not work in people. "Scaling up
the method to make it suitable for use in humans will be a
significant challenge, but not impossible," Dewhirst said.
For now, the plan is to launch more studies with animals to see
if the technique works as a way to test cancer drugs.
More information
Learn more about cancer from the
U.S. National Institutes of Health.
