MONDAY, April 14 (HealthDay News) -- A molecule that disrupts
the oncogene that causes Ewing's sarcoma has been identified by
Georgetown University Medical Center researchers.
Ewing's sarcoma is a rare cancer that strikes children and young
adults and can cause tumors to grow anywhere in the body. About 500
cases are diagnosed each year in the United States. Treatment
involves a combination of five different chemotherapy drugs. An
estimated 60 percent to 70 percent of patients survive over time,
but many experience lingering effects from the chemotherapy.
Ewing's sarcoma occurs when there's an exchange of DNA between
two chromosomes, a process called translocation. The EWS gene on
chromosome 22 fuses to the FLI1 gene on chromosome 11, creating a
new gene called EWS-FLI1, which produces the fusion protein that's
causes cancer.
If further research shows that this newly identified molecule is
effective, it could offer the first targeted therapy to treat
Ewing's sarcoma, the researchers said. The molecule works through a
so-called protein-protein interaction and could provide a model
upon which to design other therapies.
"I think this holds really wonderful promise as a unique way of
targeting fusion proteins," lead investigator Dr. Jeffrey Toretsky,
a pediatric oncology physician and researcher at Georgetown
University's Lombardi Comprehensive Cancer Center, said in a
prepared statement.
"People thought it wasn't possible to have a small molecule that
can bind between flexible proteins, but we have shown that it can
be done," Toretsky said.
He noted that the study was conducted in laboratory cells, so
further research is needed before the molecule can be tested in
humans.
The study was to be presented Sunday at the annual meeting of
the American Association for Cancer Research, in San Diego.
More information
The U.S. National Library of Medicine has more about
Ewing's sarcoma.
